It is a rapidly fatal infection which requires early diagnosis and prompt treatment. It can also occur in non-HIV patients who are immunodefecient due to chronic glucocorticoid use, organ transplantation, malignancy and sarcodiosis. Serotypes A, D and AD hybrids are globally responsible for 98% of all cryptococcal infections in AIDS patients, whereas serotypes B and C predominantly affect immunocompetent individuals, but also have been recently reported in AIDS patients.Ĭryptococcal meningitis is a fatal opportunistic neuroinfection and an AIDS defining illness seen in up to 69% of HIV-positive patients. Till date five serotypes have been described. This disease is under-reported from Uttarakhand and therefore calls for further research from this region.Ĭryptococcosis is an acute, subacute or chronic fungal infection caused by encapsulated heterobasidiomycetous yeast like fungus Cryptococcus neoformans. Conclusion:Ĭryptococcal meningitis is a rapidly fatal condition which requires a high index of suspicion and calls for a collective effort from family physicians and diagnosticians alike. Cryptococcus neoformans var grubii was the most common isolate (2/4 50%) followed by Cryptococcus neoformans var neoformans (1/4 25%) and Cryptococcus neoformans var gattii (1/4 25%), respectively. The prevalence of cryptococcal meningitis in our study was 1.09% (4/364). were obtained in culture from 51, 21 and 4 samples, respectively. Out of 364 CSF samples received, 288 were sterile after 48 hours of aerobic incubation. Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry ( MALDI-TOF-MS) was used for identifying all bacterial (except M. These samples were further subjected to fungal culture on Sabouraud's dextrose agar. Ziehl Neelsen staining, solid culture for Mycobacterium tuberculosis on Lowenstein Jensen medium and Gene Xpert was also performed on all CSF samples. All samples were subjected to examination by direct wet mount, Gram stain and India ink preparation. CSF samples of 364 patients were received by Microbiology laboratory during this period for the purpose of aerobic bacterial, fungal and TB culture, respectively. Materials and Methods:Ī cross-sectional study was conducted in a tertiary care hospital from July to December 2018. Cryptococcal meningitis is a fatal opportunistic neuroinfection and an AIDS defining illness.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |